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It helps that tirzepatide mimics two gut hormones rather than one GIP as well as GLP-1 which is why its trials show even bigger weight loss

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11 An important prerequisite is to assess exactly the GLP1 receptor (GLP1R) expression in human thyroid and pancreas, as the presence of these receptors in these tissues may be the molecular basis for the deleterious actions of GLP1 analogs

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If side effects like nausea are the concern, talking with a healthcare provider about dose adjustments is safer than skipping weeks, since lower weekly doses provide steadier, gentler medication exposure than double-strength doses every 14 days