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At the highest doses studied (8mg and 12mg), participants experienced mean resting heart rate increases of approximately 57 beats per minute (bpm) above baseline

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Elevated N-methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform

The published human trials from the 1980s used 25 nmol/kg intravenously for short courses, typically four to seven nights, in chronic-insomniac volunteers

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