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Most patients (98.1%) used one or more antihyperglycemic medications at baseline

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[24] This results in decreased concentrations of vitamin K and vitamin K hydroquinone in tissues, such that the carboxylation reaction catalyzed by the glutamyl carboxylase is inefficient

Most available studies are preclinical or conducted on small human samples, which limits the ability to conclusively state their long-term efficacy and safety

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