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Interestingly, recent studies have proposed that DNA methylation can lead to the exclusion of a histone variant (H2A.Z), preferentially located at active gene promoter 36,37

it promotes nucleic acid synthesis in nerves, improves protein synthesis in nerves, promotes axon regeneration and myelination, repaires the injured peripheral nerve to improve numbness and pain

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To increase therapeutic efficacy, many current efforts are focused on combination approaches, integrating CSC-directed inhibitors with metabolic modulators, immune checkpoint blockade, and epigenetic therapies to overcome resistance and improve long-term patient outcomes

Patients using tirzepatide should maintain regular communication with their healthcare provider and know when to seek medical attention