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PTX-3 was found to be an independent inflammatory marker correlated with the presence of LV diastolic dysfunction and HFpEF ( Table 1 ).49 In the CANTOS trial, when canakinumab succeeded in lowering high-sensitivity CRP below 2 mg/l, the likelihood of HF hospitalisation was lower.50 This study did not discriminate between HFrEF and HFpEF, yet patients were old and had a high prevalence of obesity, diabetes and arterial hypertension

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Thyroid tumors have been reported in rodents given GLP analogs and thyroid C-cell hyperplasia has been reported in humans