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Once in the nucleus, NF-B regulates gene expression, activating different genes depending on its composition, with many involved in inflammation, cell growth, and differentiation

It has been suggested to include up-regulation of growth factors [25], proangiogenic effect [26,27], and modulation of nitric oxide (NO) synthesis

Additionally, the increase in the density of SynTom inputs to the PVH of GCG-Cre-SynTom::Lep ob/ob mice did not appear to be associated with any changes in the density or distribution of PPG neurons (Figure 3JL), suggesting that leptin impacts targeting of axons to the PVH, but does not alter PPG neuron number

Welsh J, Amini A, Likhacheva A, Erasmus J J, Gomez D, Davila M, Mehran RJ, Komaki R, Liao Z, Hofstetter WL , Lee H J, Bhutani MS, Ajani JA

Singh, P., Rawat, A., Alwakeel, M., Sharif, E., & Khodor, S