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Because varenicline has been found to be consistently more effective than other pharmacotherapies for smoking cessation in adults and has demonstrated encouraging secondary abstinence outcomes in two adolescent smoking cessation randomized controlled trials (33, 34), we will conduct a rigorous three-armed randomized controlled trial in nicotine dependent adolescents of biochemically validated vaping abstinence with varenicline, combined with brief, lay counselor delivered behavioral counseling and texting support (27, 29, 30, 33)

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[4] In reality, however, the tobacco found under this paper wrap which is not "smoked" by machine is still available to and smoked by the human smoker