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Long-term use may also lead to cardiovascular complications, including blood vessel damage, high blood pressure, and irregular heart rhythms

Tob Induc Dis 21:19

In fact, according to Nicotinell, your body takes up only approximately 1 milligram of nicotine from a cigarette

Pre-1800 [edit] The coughing, throat irritation, and shortness of breath caused by smoking are obvious, and tobacco was criticized as unhealthy long before the invention of the clinical study