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Biomedicines (2022) 10:948

Melatonins potential to strengthen the BBB appears to involve the upregulation of tight junction proteins, including claudin-5, zonula occludens-1, and occluding [191], which help shield the brain from harmful substances in the bloodstream [192]

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(5) coupling Fmoc-AEEA-OH according to the side chain structure of the semaglutide, removing an Fmoc protective group, and then sequentially coupling Fmoc-AEEA-OH, Fmoc-Glu-OtBu and octadecanedioic acid mono-tert-butyl ester