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GLP-1 drugs may help with appetite and weight reduction, but they may also create clinically meaningful nutritional side effects, especially in patients with poor baseline diet quality, prolonged use, gastrointestinal side effects, or rapid weight loss

In: Nandula VK (ed) Glyphosate resistance in crops and weeds: history, development, and management

The STEP (Semaglutide Treatment Effect in People with Obesity) trials involved thousands of participants and demonstrated significant weight loss results while monitoring safety: Most participants experienced 15-20% weight loss over 68 weeks The safety profile was consistent with other GLP-1 receptor agonists Discontinuation rates due to adverse events were about 7% (compared to 3.1% with placebo) Trial participants maintained regular medical supervision throughout The STEP-1 trial, published in the New England Journal of Medicine, showed that semaglutide produced greater weight loss than any other FDA-approved anti-obesity medication to date, with a safety profile deemed acceptable by medical authorities

McFarland LV

Eur J Clin Microbiol Infect Dis (2015) 34:213947