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Kennedy, Jr., Secretary, Department of Health and Human Services.

10.1080/15548627.2015.1052208 97 PileticK.AlsalehG.SimonA

Two complementary lineagessystem Xc inhibitors and GPX4-directed agentsoffer improvements in potency, stability, or solubility, yet translation is constrained by on-target depletion of cystine and glutathione in normal tissues and by off-target perturbations, including mitochondrial channel engagement and p53 pathway modulation, which collectively narrow the therapeutic index

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