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Once this treatment is discontinued, repigmentation will likely occur in the affected areas, although patients can continue to be managed with other treatments

This approach minimizes the gap and prevents significant drops in medication concentration

In MAD cohort 1 (100 mg/12 h), one participant was withdrawn from the study, following the advice of the Safety Review Committee, due to an event of proteinuria deemed mild and unrelated to study treatment, and most probably related to a pre-existing renal disease that was not detected during the screening period

Ozempic works by acting like a hormone called GLP-1

The mechanism operates through upstream modulation of inhibitor of kappa B (IkB) kinase activity, which normally phosphorylates and degrades IkB proteins, freeing NF-kB to drive inflammatory gene transcription