The CREDENCE (Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation) trial predominantly studied renal outcomes, and reported that patients with type 2 diabetes and chronic kidney disease who received canagliflozin had a lower risk of the primary composite outcome of end-stage kidney disease, doubling of the serum creatinine level, or death from renal or cardiovascular causes than those who received a placebo
Effects of semaglutide on eating behaviour, appetite, and food choices
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They work through several mechanisms that are relevant even when your pancreas no longer makes insulin: they slow gastric emptying (meaning food hits your bloodstream more gradually), suppress glucagon release (the hormone that raises blood sugar), and reduce appetite
They act in the brain to increase the feeling of satiety (not being hungry anymore), which stops overeating and excessive drinking
