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Interaction and subgroup analyses demonstrated that glucagon-like peptide-1 (GLP-1) was positively related to total energy ( = 0.268, P = 0.033), carbohydrates intake, and insulin secretion ( = 2,045.2, P = 0.003) only in the acarbose group, while systolic blood pressure (SBP) was negatively related to protein intake in the metformin group ( = 23.21, P = 0.014)

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A coffee enema rather than an oral dose was utilized in this study because 1 L of coffee extract is difficult to ingest in addition to the customary 2 L of PEG, and the coffee solution itself could impede VCE

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Ipamorelin is considered to have a more favorable metabolic profile