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The molecular explanation involves multiple synergistic pathways

Its role in angiogenesis (via endothelial differentiation and laminin-5 production) and cell survival (through Akt and integrin-linked kinase signaling) makes it an essential factor for broad tissue recovery

But that doesn't stop them normally

The mitochondrial fusion/fission-associated proteins Mfn2 and Drp1 have been proposed to function as downstream nuclear transcription factors in the PGC-1-mediated mitochondrial biogenesis process (Peng et al., 2017)