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The McCoy 2013 paper, which introduced and characterized Dihexa as the metabolically stabilized lead from the Harding laboratorys Ang IV-analog series, used scopolamine-induced cognitive impairment in young rats and natural cognitive decline in aged rats as the primary Morris water maze readouts

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Signorelli SS, Malaponte MG, Di Pino L, Costa MP, Pennisi G, Mazzarino MC (2000) Venous stasis causes release of interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFalpha) by monocyte-macrophage