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This study investigates these properties using a p-chlorophenylalanine (PCPA) -induced insomnia model in mice, an approach akin to traditional methods evaluating sleep-promoting activities in fusion peptides

However, it is important to note that the analysis of the present review focused primarily on the folate-dependent pathway, which constitutes a limitation because it excludes other nutrients involved in epigenetic regulation, such as choline, serine and vitamins B12 and B6, all of which participate in SAM availability and overall methylation capacity (175,176)