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Other features include neurovascular structural damage caused by mechanical factors, secondary oedema formation, decreased cerebral perfusion levels, and increased glutamate levels (107110)

It is clear that neither X-ray crystallography nor cryo-EM can obtain a high resolution structure for intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) because of a very simple reason: unlike ordered, well-folded proteins and domains, IDPs/IDRs do not adopt a single, stable three-dimensional structure

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