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At the highest concentration of 5800 M, both CuCl 2 and Cu(OAc) 2 were found to be very cytotoxic to the cells and almost all the cells were dead at the three time points

Acknowledgment Authors acknowledge the financial support given by the Indian Council of Medical Research, New Delhi

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These findings indicate that GPX3 and MYC may play central roles in RA-related immune-inflammatory regulation and metabolic imbalance, potentially influenced by gut microbiota and their metabolites