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Multivariable-adjusted analysis showed that GLP-1 RA use had significantly lower risks of all-cause mortality (aHR 0.48, 95%CI 0.430.53), cardiovascular events (aHR 0.92, 95%CI 0.860.99), cardiovascular death (aHR 0.57, 95%CI 0.450.72), and liver-related death (aHR 0.32, 95%CI 0.130.75)

Storage requirements Refrigerate at 2-8 degrees Celsius (36-46 degrees Fahrenheit) Protect from light, especially direct sunlight Do not freeze After first puncture, note the date and discard after the beyond-use date (typically 28-60 days) Brief room temperature excursions (under 30 minutes for injection prep) do not affect potency Our tirzepatide refrigeration guide covers the science behind storage requirements

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