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Users stopping retinoids frequently report rapid regression of benefits within 4-8 weeks including increased breakouts sometimes exceeding pre-treatment levels (retinoid rebound), accelerated fine line reappearance approaching or surpassing baseline, skin texture deterioration returning to pre-treatment roughness, and psychological dependency from dramatic visible decline creating pressure for continuous use despite side effect burden

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Nevertheless, the thiol group is the main chemically reactive group with respect to its biological and biochemical functions (Zagorchev et al

Ribomin S is a set of ampoules of 1 ml each, containing vitamins B2 and B6