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The growth hormone receptor: Mechanism of receptor activation, cell signaling, and physiological aspects

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doi: 10.1016/j.arr.2021.101481 56 HuWChenYDouCDongS

Research utilizing the Broad Institute's Connectivity Map indicates it influences the expression of over 4,000 genes (~31% of the human genome), shifting gene signatures from a pathological state back to a healthier, regenerative baseline

Under the same experimental format as Figure 1e left column, except using a molar ratio of GSSSG and LASSS to HGF (1:8000), LASSS-treated HGF (Figure 1e right column, bar 9 ) displayed about 2-fold higher c-met binding than the control HGF level ( bar 8 , in which HGF just received the solvent) equivalent to the positive controls ( bars 2 and 2 in the left column)