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Tirzepatide (Mounjaro) a dual GLP-1/GIP agonist licensed in the UK for type 2 diabetes and, following a positive NICE technology appraisal (TA1026), recommended for weight management in eligible adults within specialist services

Early non-peptidic compounds such as TT-OAD2 provided initial proof that direct engagement of the TM pocket by small molecules could promote GLP-1R activation (Zhao et al., 2020)

Moreover, gut microbiota dysbiosis in gout results in a reduction of microbial populations responsible for producing BSH and 7-dehydroxylase

This helps to regulate appetite control and blood sugars

Significant alterations in body fat homeostasis and glucose tolerance have been observed in ZnT8 knockout mouse strains