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The combination of these agents with SGLT2 inhibition is particularly interesting considering the natriuresis and protection against HF outcomes associated with SGLT2i [76]

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The first identified agent was hydroquinone monobenzyl ether (monobenzone), which induces cell death without activating the caspase cascade or DNA fragmentation.98 Rhododendrol, another phenolic compound used in skin lightening treatments responsible for an outbreak of leukoderma in Japan, promotes cytotoxicity via a tyrosinase-dependent mechanism.99 Hair dyes have also been implicated in the appearance of leukoderma, and one of the main suspects is paraphenylenediamine

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Date: June 5, 2026 Source: Stanford Medicine Summary: Scientists have identified genetic variants that may make some people less responsive to GLP-1 drugs used to treat Type 2 diabetes