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ERJ Open Res (2023) 9(3):006332022

Together, these findings suggest that cellular resistance to cuproptosis also depends on a hierarchically organized copper-buffering system, in which mtGSH provides rapid, dynamic metal buffering, whereas metallothioneins confer sustained high-affinity sequestration to prevent mitochondrial copper overload

Daphnetin triggers ROS-induced cell death and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway in ovarian cancer