Central/peripheral administration of GLP-1RAs inhibits food intake, accompanied by an increase in c-Fos expression in neurons within the paraventricular nucleus (PVN), amygdala, the nucleus of the solitary tract (NTS), area postrema (AP), lateral parabrachial nucleus (LPB) and arcuate nucleus (ARC), induced by the activation of GLP-1 receptors in the central nervous system (CNS)
Further reading on how this affects pre- versus post-prandial blood sugar found here
Start your intake How Naltrexone and Semaglutide Work in the Body Semaglutide activates GLP-1 receptors in the brain and gut, signaling fullness, slowing gastric emptying, and reducing hunger hormones like ghrelin
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If youve taken a breakwhether because of cost, side effects, or life changesyoull likely need to restart at a lower dose and work your way up again