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Ozempic (for diabetes) typically follows a 4-week titration schedule, while Wegovy (for weight management) uses a more gradual 16-20 week titration approach

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The higher efficacy of tirzepatide, as shown here, comparing it with the highest approved dose of selective GLP1 RA semaglutide for the management of T2D, is probably a result of the additional GIP RA activity associated with tirzepatide

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Both peripheral gut effects and central brainstem modulation likely lower the hiccup reflex threshold, with a pharmacovigilance review finding 25 of 500 adverse reports involved hiccups (5%), and some trials noting hiccups in about 2% of participants