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The short half-life reflects rapid clearance and ligand exchange with serum proteins such as albumin and ceruloplasmin

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The systemic chemotherapy resulted in one complete response and three partial responses in a total of five patients, suggesting that this therapy may be an option for treatment of extensive lesions.[262] A dose reduction of 30% to 50% has been recommended for systemic chemotherapeutic agents in this population because of the increased sensitivity of XP cells.[263] For patients with EB, wide local excision of SCC with 2 cm margins remains the treatment of choice

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