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21, 2004, GSK: Knowingly promoted the sale and use of Zofran for a variety of conditions other than those for which its use was approved as safe and effective by the FDA (including hyperemesis and pregnancy-related nausea) Made and/or disseminated unsubstantiated and/or false representations or statements about the safety and efficacy of Zofran concerning its use for conditions, including hyperemesis and pregnancy-related nausea Offered and paid illegal kickbacks to health care professionals to encourage them to promote and prescribe Zofran, in violation of federal anti-kickback laws The DOJ described the settlement as the largest health care fraud settlement in U.S

Adjunctive Therapy Valproic acid may be added to the patient's regimen at a dosage of 10 to 15 mg/kg/day

There's lots of clinicians who are starting to use just a low dose

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GoodSense Anti-Diarrheal Medicine, Loperamide Hydrochloride Oral Solution, provides effective relief from diarrhea symptoms