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As a transcriptional suppressor, Hes1 in the retina inhibits the differentiation of specific cell types and leads to excessive gliosis, increased inflammatory cytokine release, and ECM imbalance

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[55] This cascade alters cellular energy dynamics, ultimately triggering the influx of calcium into the cell, which prompts the exocytosis (release) of insulin-containing vesicles into the bloodstream

Glucagon-like pepetide-1 GLP-1 is an incretine hormone that has a pivotal role in metabolic processes

GLP-1 medications work by binding to receptors that control hunger signals and glucose metabolism, creating a more comprehensive metabolic effect than phentermine alone