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The main goal of 3D cultures is to provide cells with a bulk ECM with properties that guide cells to develop or sustain a desired phenotype and, implicitly, to rely upon the cells themselves to create a local 3D microenvironment that mimics the in vivo microenvironment
This would benefit the pet with pain and/or paralysis
A synthetic form of this peptide, called Exenatide, was the first incretin analog approved by the US FDA to treat diabetes
174 One reason for inconsistent results may be the lack of a standardized protocol, including dose of pulses and duration of treatment
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