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However, the optimal dosage, administration route and long-term safety of NADPH precursors remain unvalidated in large animal models, and the crosstalk of NADPH metabolism, iron homeostasis and retinal inflammation is poorly understood, limiting clinical translation of NADPH-targeted therapies and requiring further investigation

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Most clinicians recommend maintaining your dose for 4-8 weeks after reaching your goal, then reducing by 25-50% every 2-4 weeks

MOTS-c has also garnered attention for possible benefits related to aging