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The peptide increases expression of 14 antioxidant genes while suppressing 2 pro-oxidant genes, creating a cellular environment more resistant to oxidative stress

10.1016/j.neuroscience.2006.09.064 61 ChiaR.ChiA.TraynorB

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Targeting FIT2, a protein essential for LD formation, the authors demonstrated reducing LD accumulation in brain macrophages could restore their pathological phenotypes in an AD mouse model (Wu et al., 2025)

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