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Overstimulation of growth pathways may cause enlargement of bones in the hands, feet, or jaw, soft tissue thickening, and in severe cases, organomegaly (enlargement of organs)

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Eine entsprechende Wirksamkeit auch bei Patienten, bei denen allein aufgrund des Vorliegens von Risikofaktoren ein erhhtes kardiovaskulres Risiko angenommen werden muss, ist nach wie vor umstritten

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