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This suppressive TME arises from a combination of factors, including hypoxia (4145), overexpression of reactive oxygen species (ROS)-scavenging molecules like glutathione (GSH) (4649), infiltration of immunosuppressive cells such as regulatory T cells (Tregs) (5054), and myeloid-derived suppressor cells (MDSCs) (5558), and inherently low tumor immunogenicity (5964)

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The effect of topical tripeptide-copper complex on healing of ischemic wounds in rats