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Furthermore, in silico studies showed interaction of 7 nAChRs with RBDs of SARS-CoV-2 spike glycoproteins, indicating dysregulation of the nicotinic cholinergic system and leading to cytokine storm in COVID-19 patients [332, 333]

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Cigarette smoke-induced effects on bone marrow B-cell subsets and CD4+:CD8+ T-cell ratios are reversed by smoking cessation: influence of bone mass on immune cell response to and recovery from smoke exposure