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Description

Shirazi RH, Dickson SL, Skibicka KP

Following receptor-ligand interaction, the signal is transmitted via the Disheveled (Dvl) protein, which modulates the activity of several key regulators, including axis inhibition protein (Axin), adenomatous polyposis coli (APC), and glycogen synthase kinase-3 (GSK-3) [145]

This indicates that their cardiometabolic benefits are primarily mediated by weight loss, IR alleviation, and improvements in triglyceride-rich lipoprotein pathways, rather than a direct reduction in LDL-C levels