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Autologous hematopoietic stem cell transplants have been performed in a few cystinosis patients based upon the premise that tunneling nanotubes transport lysosomes bidirectionally between the stem cells and the patients parenchymal cells [158]

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The inhibition of PI3K/Akt and ERK1/2 also significantly decreased NAMPT-induced VEGF expression and activation, leading to important inhibition of endothelial cell proliferation and in the formation of new vessels