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2024;36: e2311283

FOXO4-DRI's theoretical selectivity advantage over small-molecule senolytics has not been tested in humans

Since estradiol varies over a very wide range during the menstrual cycle, one might expect that GSH would show similar variability

The failure of NE inhibitors alone (116), and the data for brensocatib in the Phase 2 WILLOW trial (115, 202), suggests that combined inhibition of NSPs, as well as inhibition prior to extracellular release by the neutrophils, may be required for observation of efficacy in bronchiectasis

Poorly reconstituted solutions form depots that artificially extend apparent half-life through delayed release rather than prolonged circulation