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In addition to the examples listed in the last section, embryonic deletion of Dnmt3a results in neuronal dysfunction, such as hypoactivity, motor abnormalities, decreased neuromuscular function, fewer motor neurons, and a shortened lifespan [73]

Systemic reactions may include gastrointestinal disturbances (nausea, diarrhea, abdominal cramps) when large doses are administered intravenously

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