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Additionally, side effects are common but generally temporary

A dose injected into lipohypertrophic tissue may absorb unpredictably, leading to inconsistent blood levels and reduced effectiveness

Use in Specific Populations (8.6).] When JANUVIA was used in combination with insulin or insulin secretagogues (e.g., sulfonylurea), medications known to cause hypoglycemia, the incidence of hypoglycemia was increased over that of placebo used in combination with a sulfonylurea or with insulin

Despite advances with RAAS inhibitors, SGLT2 inhibitors, and nonsteroidal MRAs, residual kidney risk remains high

Imperial College London Society of Endocrinology