This interplay contributes to neuronal dysfunction and apoptosis in neurodegenerative diseases like AD, and cardiomyocyte apoptosis in cardiovascular diseases [72, 73]
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When pharmaceutical researchers began testing GLP-1 analogs in diabetic patients during the 1990s, they noticed an unexpected side effect: patients experienced significant appetite suppression and weight loss
This beneficial outcome is largely attributed to the decreased leptin levels in the bloodstream and tibia, alongside the inhibition of hyperlipidemia-associated leukocytosis progression, a decline in the accumulation of immune cells in the aorta, accompanied by smaller atherosclerotic plaques at the aortic root