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American Tobacco Campus 300 Blackwell Street Downtown Durham North Carolina 27701 United States Telephone: n/a E-mail: [email protected] Website Open Varies by venue

Second, barely one year after the Deeming Rule became final, FDA substantially deregulated e-cigarettes by issuing a Guidance purporting to suspend premarket review of e-cigarettes that were on the market as of the effective date of the Deeming Rule by extending the deadline for filing PMTAs for four years (until August 2022)

In line with the hypothesis that epithelium from control smokers is better protected against cigarette smoke-induced changes in mitochondrial function, OXPHOS complex levels were not (persistently) higher in PBECs from smokers with normal lung function than from never-smokers, although OXPHOS complex II, III and VF1 were increased upon long-term CSE exposure in BEAS-2B

Juul did not respond to ABC News' request for comment on the lawsuit