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For patients on Hydrocodone Bitartrate and Acetaminophen Tablets who are physically opioid-dependent, initiate the taper by a small enough increment (e.g., no greater than 10% to 25% of the total daily dose) to avoid withdrawal symptoms, and proceed with dose-lowering at an interval of every 2 to 4 weeks

10.1172/JCI90328 J

The following cycling programme was used: 10 min at 95C

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