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The third on our 3 Different Types of B12 list is Hydroxycobalamin is another form of vitamin B12 that is used in injections to treat vitamin B12 deficiency

It's particularly compelling for patients who haven't achieved adequate response with semaglutide or tirzepatide, those with obesity and concurrent knee osteoarthritis, patients with metabolic liver disease, and anyone with a significant cardiovascular risk factor burden

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However, in a recent abstract, the interim analysis of the REGENERATE trial showed lower patient-reported outcomes than the general population on a specific questionnaire (the chronic liver disease questionnaire-NASH), and the patient-reported outcomes improved with OCA treatment