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Simultaneously, ROS activate PKC isoforms and the AGE-RAGE signaling cascade, which upregulate pro-inflammatory cytokines (TNF-, IL-6) and adhesion molecules (VCAM-1, ICAM-1) through NF-B activation (Gonzlez et al., 2023)

Other anti-inflammatory and antioxidant dietary supplements, such as folic acid, inositol, vitamin E, omega-3 fatty acids, alpha lipoic acid, N-acetylcysteine, have shown potential adjuvant therapeutic effects by ameliorating IR, lipid profile, reducing inflammation and oxidative stress markers of PCOS (227229, 250255)

The question that has never been formally answered is whether those mechanisms translate into measurable clinical benefit in humans under controlled conditions

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Suboptimal or deficient glutathione levels have been associated with various chronic and age-related conditions, including neurodegenerative diseases, mitochondrial dysfunction, and certain types of cancer