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doi: 10.1183/13993003.01702-2020 111 GramegnaAAmatiFTerranovaLSotgiuGTarsiaPMigliettaDet al

Patients with genetic variations that enhance GLP-1 receptor signaling may feel full and nauseated more intensely at standard dosesa signal to start lower and titrate slowly rather than push toward higher doses

WARNING: Risk of Thyroid C-Cell Tumors In animal studies, GLP-1 receptor agonists have been associated with thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)

Physicians evaluate individual candidates based on BMI thresholds (30 or 27 with weight-related comorbidities), cardiovascular risk, metabolic history, and contraindications

PMID 8856015