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1 Physician-Led Review STEP Dr

The physiological effects of PYY are mediated through a family of NPY receptors (termed Y1, Y2, Y3, Y4, and Y5), which are differentially expressed in a wide range of tissue including enterocytes, myenteric and submucosal neurons and extrinsic primary afferent nerve fibers (123)

Factors such as individual metabolism, overall health, and concurrent medications can all influence how one experiences fatigue while on GLP-1 therapy

There is also no information on the rate of failed GUS imaging, despite reported failure rates of up to 10% in the literature

Your provider may slow dose escalation or maintain a lower dose if you experience persistent gastrointestinal symptoms