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In addition, BMS-754807 treatment induced phosphorylation of mitogen-activated protein kinase kinase 1 and 2 (MEK1/2), which contributed to BMS-754807-induced p70S6K1 activation for survival in colon cancer cells
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Tripathi A, Lammers KM, Goldblum S, Shea-Donohue T, Netzel-Arnett S, Buzza MS, Antalis TM, Vogel SN, Zhao A, Yang S, Arrietta MC, Meddings JB, Fasano A
[Cut to Amy Lynn.] Amy Lynn, speaking: Patients who are starting them just need to be aware that they may have some GI side effects including nausea, vomiting, constipation or diarrhea
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