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Among the members of the caspase family, caspase-3 is a crucial modulator of apoptosis in mammalian cells [42]

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Three disulfide bonds (Cys336Cys361, Cys379Cys432, and Cys391Cys525) stabilize the sheet structure of the core, while a fourth pair (Cys480Cys488) connects loops in the distal end of the RBM [43]